Faculty Publications

Mark Arnold

Smith, R. M. and Arnold, M. A. (2015). "Selectivity of Terahertz Gas-Phase Spectroscopy." Anal Chem 87(21): 10679-10683.

Rupasinghe, T. P., Hutchins, K. M., Bandaranayake, B. S., Ghorai, S., Karunatilake, C., Bucar, D. K., Swenson, D. C., Arnold, M. A., MacGillivray, L. R. and Tivanski, A. V. (2015). "Mechanical Properties of a Series of Macro- and Nanodimensional Organic Cocrystals Correlate with Atomic Polarizability." J Am Chem Soc 137(40): 12768-12771.

Gregory Carmichael

Dewan, N., Majestic, B. J., Ketterer, M. E., Miller-Schulze, J. P., Shafer, M. M., Schauer, J. J., Solomon, P. A., Artamonova, M., Chen, B. B., Imashev, S. A. and Carmichael, G. R. (2015). "Stable isotopes of lead and strontium as tracers of sources of airborne particulate matter in Kyrgyzstan." Atmospheric Environment 120: 438-446.

Miller-Schulze, J. P., Shafer, M., Schauer, J. J., Heo, J., Solomon, P. A., Lantz, J., Artamonova, M., Chen, B., Imashev, S., Sverdlik, L., Carmichael, G. and DeMinter, J. (2015). "Seasonal contribution of mineral dust and other major components to particulate matter at two remote sites in Central Asia." Atmospheric Environment 119: 11-20.

​Michael Duffel

Rodriguez, E.A., Vanle, B.D., Doorn, J.A., Lehmler, H.-J., Robertson, L.W., and Duffel, M.W. 2018. “Hydroxylated and Sulfated Metabolites of Commonly Observed Airborne Polychlorinated Biphenyls Display Selective Uptake and Toxicity in N27, SH-SY5Y, and HepG2 Cells.” Environmental Toxicology and Pharmacology.  62:69-78.  PMCID: PMC6092199.

Parker, V.S., Squirewell, E.J., Lehmler, H.-J., Robertson, L.W., and Duffel, M.W. 2018. “Hydroxylated and Sulfated Metabolites of Commonly Occurring Airborne Polychlorinated Biphenyls Inhibit Human Steroid Sulfotransferases SULT1E1 and SULT2A1.” Environmental Toxicology and Pharmacology 58: 196-201.  PMCID: PMC6078096.

Dhakal, K., Gadupudi, G.S., Lehmler, H.-J., Ludewig, G., Duffel, M.W., and Robertson, L.W. 2018. “Sources and Toxicities of Phenolic Polychlorinated Biphenyls (OH-PCBs).” Environmental Science and Pollution Research. 25:16277-16290. PMCID: PMC5785587.

Duffel, M.W.  2017.  “Sulfotransferases.”  In: McQueen, C.A., Ed., Comprehensive Toxicology, 3rd Edition.  Vol. 10, pp. 407-428. Elsevier, Oxford.

Grimm, F.A., Lehmler, H.-J. Koh, W.X., DeWall, J., Teesch, L.M., Hornbuckle, K.C., Thorne, P.S., Robertson, L.W., and Duffel, M.W. 2017. “Identification of a sulfate metabolite of PCB 11 in human serum.” Environment International. 98:120-128. PMCID: PMC5127762.

Rodriguez, E.A., Li, X., Lehmler, H.-J., Robertson, L.W., and Duffel, M.W.  2016.  “Sulfation of lower chlorinated polychlorinated biphenyls increases their affinity for the major drug-binding sites of human serum albumin.” Environmental Science and Technology. 50:5320-5327.  PMCID: PMC4883002.

Ekuase, E., van’t Erve, T.J., Rahaman, A., Robertson, L., Duffel, M., and Luthe, G.  2016. “Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes.”  Environmental Science and Pollution Research, 23:2119-2127.  PMCID: PMC4713379.

Grimm, F.A., He, X., Teesch, L., Lehmler, H.-J., Robertson, L., and Duffel, M.W. 2015. "Tissue distribution, metabolism and excretion of 3, 3’-dichloro-4’-sulfooxy-biphenyl in the rat." Environmental Science and Technology, 49:8087-8095. PMCID: PMC4496304

Squirewell, E.J. and Duffel, M.W. 2015. “The Effects of Endoxifen and Other Major Metabolites of Tamoxifen on the Sulfation of Estradiol Catalyzed by Human Cytosolic Sulfotransferases hSULT1E1 and hSULT1A1*1.” Drug Metabolism and Disposition, 43:1-8. PMCID: PMC4429681.

Grimm, F.A., Lehmler, H.-J., He, X., Robertson, L.W. and Duffel, M.W. 2015. “Modulating Inhibitors of Transthyretin Fibrillogenesis via Sulfation: Polychlorinated Biphenyl Sulfates as Models.” Chemico-Biological Interactions, 228:1-8. PMCID:PMC4327905

Grimm, F.A., Kania-Korwel, I., Lehmler, H.-J., Ludewig, G., Hornbuckle, K.C., Duffel, M.W., Bergman, A., and Robertson, L.W. 2015. “Metabolism and Metabolites of Polychlorinated Biphenyls (PCBs).” Critical Reviews in Toxicology, 45:245-272.  PMCID:PMC4383295.

Adrian Elcock

Cressiot, B., Braselmann, E., Oukhaled, A., Elcock, A. H., Pelta, J. and Clark, P. L. (2015). "Dynamics and Energy Contributions for Transport of Unfolded Pertactin through a Protein Nanopore." ACS Nano 9(9): 9050-9061.

Jennifer Fiegel

B. Givens, E. Wilson, J. Fiegel. The effect of salts in aqueous media on the formation of the BSA corona on SiO2 nanoparticles. Colloids Surf. B, 179: 374-381 (2019).

B.E. Givens, N.D. Diklich, J. Fiegel, V.H. Grassian. Adsorption of bovine serum albumin on silicon dioxide nanoparticles: Impact of pH on nanoparticle-protein interactions. Biointerfaces. 12, 02D404 (2017).

S. Sommerfeld Ross, S. Gharse, L. Sanchez, J. Fiegel. Dry powder aerosols to co-deliver antibiotics and nutrient dispersion compounds for enhanced bacterial biofilm eradication. Int. J. Pharm. 2017; 531(1): 14-23.B.E. Givens, Z. Xu, J. Fiegel, V.H. Grassian. Bovine serum albumin adsorption on SiO2 and TiO2 nanoparticle surfaces at circumneutral and acidic pH: A tale of two nano-bio surface interactions. J. Colloid Interface Sci. 2017; 493: 334-341.

A. Farnoud, J. Fiegel. Calf lung surfactant recovers surface functionality after exposure to aerosols containing polymeric particles. J. Aerosol Med. Pulm. Drug Deliv. 2016; 29(1): 10-23.

James Gloer

Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.  Dischler, N.M.; Xu, L.; Li, Y.; Nichols, C.B.; Alspaugh, J. A.; Bills, G.F.; Gloer, J. B.  J. Nat. Prod. 2019, 82, 532−538.  

Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay.  Xu, L.; Li, Y.; Gloer, J. B.; Alspaugh, A.; Bills, G. F., Appl. Microbiol. Biotechnol. 2018, 102, 2337-2350. 

New anti-Cryptococcus phenalenones and cyclic tetrapeptides from Auxarthron pseudauxarthron.  Li, Y.; Yue, Q.; Jayanetti, D.R.; Swenson, D. C.; Bartholomeusz, G A.; An, Z.; Gloer, J. B.; Bills, G.F.  J. Nat. Prod., 2017, 80, 2010-2109.

Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora.  Jayanetti, D.R.; Li, Y.; Bartholomeusz, G.A.; Bills, G.F.; Gloer, J. B.  J. Nat. Prod. 2017, 80, 707−712.

Biologically Active Secondary Metabolites from the Fungi.  Bills, G. F.; Gloer J. B.  Microbiol. Spectr. 2016, 4, FUNK-0009-2016, 32 pp.  Subsequently appearing as Chapter 54 in The Fungal Kingdom.  Heitman, J.; Howlett, B. J.; Crous, P. W.; Stukenbrock, E. H.; James, T. Y., Gow, N. A. R., Eds.  American Society for Microbiology, Washington, DC.  2018, pp 1087-1119.

Emestrins: anti-Cryptococcus epipolythiodioxopiperazines from Podospora australis.  Li, Y.; Yue, Q.; Krausert, N.M.; An, Z.; Gloer, J.B.; Bills, G. F.  J. Nat. Prod., 2016, 79, 2357-2363.

Effect of atmospheric carbon dioxide levels and nitrate fertilization on glucosinolate biosynthesis in mechanically damaged Arabidopsis plants.  Paudel, J. R.; Amirizian, A.; Krosse, S.; Giddings, J.; Ismail, S.A.A.; Xia, J.; Gloer, J. B.; van Dam, N.M.; Bede, J.C.  BMC Plant Biology 2016, 16, 68.

Haenamindole and fumiquinazoline analogues from a fungicolous isolate of Penicillium lanosum.  Hwang, I. H.; Che, Y.; Swenson, D.C.; Gloer, J. B.; Wicklow, D. T.; Peterson, S. W.; Dowd, P. F., J. Antibiot., 2016, 69, 631-636.

New Punctaporonins from Two Fungicolous Isolates of Pestalotiopsis Sp.  Hwang, I. H.; Wicklow, D. T.; Gloer, J. B. Phytochem. Lett., 2016, 16, 257-262.   

New Monomeric Stilbenoids from Fungus-Challenged Peanut (Arachis hypogaea) Seeds.  Sobolev, V. S.; Krausert, N. M.; Gloer, J. B.  J. Agric. Food Chem., 2016, 64, 579-584.

Disseminins and Spiciferone Analogues:  Polyketide-derived Metabolites from a Fungicolous Isolate of Pestalotiopsis disseminata.  Hwang, I. H.; Swenson, D. C.; Gloer, J. B., Wicklow, D. T. J. Nat. Prod., 2016, 79, 523-530.

Cycloexpansamines A and B: Spiroindolinone alkaloids from a marine isolate of Penicillium sp. (SF-5292).  Oh, H.; Lee, C.; Sohn, J. H.; Jang, J.-H.; Ahn, J. S.; Baltrusaitis, J.; Hwang, I. H.; Gloer, J. B.  J. Antibiot., 2015, 68, 715-718. 

Pestaloporonins:  Caryophyllene-derived Sesquiterpenoids from a Fungicolous Isolate of Pestalotiopsis Sp.  Hwang, I. H.; Swenson, D. C.; Gloer, J. B., Wicklow, D. T. Org. Lett. 2015, 17, 4284–4287.

Hypocoprins A-C:  New Sesquiterpenoids from the Coprophilous Fungus Hypocopra rostrata (Xylariales).  Jayanetti, D. R.; Yue, Q.; Bills, G. F.; Gloer, J. B.  J. Nat. Prod. 2015, 78, 396-401.

Alexander Horswell

 Britton, E. R., Ibberson, C. B., Horswill, A. R. and Cech, N. B. "A new mass spectrometry based bioassay for the direct assessment of hyaluronidase activity and inhibition." Journal of Microbiological Methods.

Cassandra L. Quave , J. T. L., Jeffery S. Kavanaugh, Kate Nelson, Corey P. Parlet, Heidi A. Crosby, Kristopher P. Heilmann, Alexander R. Horswill (2015). "Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance." PLoS ONE 10(8).

Scherr, T. D., Hanke, M. L., Huang, O., James, D. B., Horswill, A. R., Bayles, K. W., Fey, P. D., Torres, V. J. and Kielian, T. (2015). "Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin." MBio 6(4).

Amnon Kohen

Morris, H., Singh, P., Kohen, A.,* Tivanski, A.,* “Probing Single Molecule Enzyme-Drug Interaction with Molecular Recognition Force Spectroscopy”, Submitted to Chem. Commun., March 18, 2016.

Guo, Q., Gakhar., L., Wickersham., K., Francis, K., Vardi-Kilshtain., A., Major, T.D., Kohen, A.,* “Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii”, Submitted to Biochemistry, Feb 28, 2016.

Francis, K., Sapienza, P.J., Lee, A.L., Kohen, A.,* “The Effect of the Protein Mass Modulation on Human Dihydrofolate Reductase”, Biochemistry, 55, 1100–1106, 2016.

Mishanina, T.V., Yu, L., Karunaratne, K., Mondal, D., Corcoran, J.M., Choi, M.A., Kohen, A.,* “An unprecedented mechanism of nucleotide methylation in organisms containing thyX”, Science, 351, 507- 510, 2016.

Kohen, A.,* “Dihydrofolate Reductase as a Model for Studies of Enzyme Dynamics and Catalysis”, F1000Research 2015, 4 (F1000 Faculty Rev):1464. (Invited Review). Islam, Z., Strutzenberg, T.S., Ghosh, A.K., Kohen, A.,* “Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction”, ACS Cat., 2015, 5, 6061–6068.

Francis, K., Kohen, A.,* “Dihydrofolate Reductase as a Model for Enzyme Catalysis”, Current Biotech., 2015, 4, 1-10. (Invited review).

Singh, P., Francis, K., Kohen, A.,* “Network of remote and local protein dynamics in dihydrofolate reductase catalysis”, ACS Cat., 2015, 5, 3067–3073.

Guo, Q., Pagano, P., Li, Y., Kohen, A., Cheatum, C.M.,* “Line Shape Analysis of Two-dimensional Infrared Spectra”, J. Chem. Phys., 2015, 142, 212427.

Ghosh, A.K., Islam, Z., Krueger, J.D., Abeysinghe, D.T., Kohen, A.,* “The General Base in the Thymidylate Synthase Catalyzed Proton Abstraction”, Phys. Chem. Chem. Phys., 2015, 17, 30867-30875.

Świderek, K., Kohen, A., Moliner, V.,* “Influence of Active Site Conformations on the Hydride Transfer step of the Thymidylate Synthase Reaction Mechanism”, Phys. Chem. Chem. Phys., 2015, 17, 30793— 30804.

Abeysinghe, T., Kohen, A.,* “Role of Long-Range Protein Dynamics in Different Thymidylate Synthase Catalyzed Reactions”, Int. J. Mol. Sci., 2015, 16, 7304-7319,. Special Issue on Protein and ProteinLingand Interactions.

Nilaweera, T., Saeed, M. and Kohen, A.,* “Targeting the de novo Biosynthesis of Thymidylate for the Development of PET Probe for Pancreatic Cancer Imaging”, Biochemistry, 2015, 54, 1287–1293. Chosen to be highlighted on the journal’s home page: http://pubs.acs.org/journals/bichaw/index.html.

Singh, P., Abeysinghe, T., Kohen, A.,* “Linking Protein Motion to Enzyme Catalysis”, Molecules, 2015, 20, 1192-1209. (Invited review)

Doron, D., Stojković, V., Gakhar, L., Kohen, A., Major, D.,* “Free Energy Simulations of Active-Site Mutants of Dihydrofolate Reductase”, J. Phys. Chem. B., 2015, 119, 906–916.

Kohen, A.,* “Role of Dynamics in Enzyme Catalysis: Substantial vs. Semantic Controversies”, Acc. Chem. Res., 2015, 48, 466–473. (Special Issue on “Enzymes Dynamics and Catalysis”)

Singh, P., Morris, H., Tivanski, A.V., Kohen, A.,* “Determination of concentration and activity of immobilized enzymes”, Anal., Biochem., 2015, 484, 169–172.

Singh, P., Morris, H., Tivanski, A.V., Kohen, A.,* “A calibration curve for immobilized dihydrofolate reductase activity assay”, Data in Brief, 2015, 4, 19-21.

Mishanina, T., Kohen, A.,* “Synthesis and application of isotopically labeled flavin nucleotides”, J. Labeled Comp. Radiopharma., 2015, 58 370–375.

Gregory H. LeFevre

Klarich Wong, K. L.; Webb, D. T.; Nagorzanski, M. R.; Kolpin, D. W.; Hladik, M. L.; Cwiertny, D. M.; LeFevre, G. H.; Klarich-Wong, K.; Webb, D. T.; Nagorzanski, M. R.; Kolpin, D. W.; Hladik, M. L.; Cwiertny, D. M.; LeFevre, G. H. Chlorinated Byproducts of Neonicotinoids and Their Metabolites: An Unrecognized Human Exposure Potential? Environ. Sci. Technol. Lett. 2019, 6 (2), 98–105 DOI: 10.1021/acs.estlett.8b00706.
https://pubs.acs.org/doi/abs/10.1021/acs.estlett.8b00706 

Ashoori, N.; Teixido, M.; Spahr, S.; LeFevre, G. H.; Sedlak, D. L.; Luthy, R. G. Evaluation of Pilot-Scale Biochar-Amended Woodchip Bioreactors to Remove Nitrate, Metals, and Trace Organic Contaminants from Urban Stormwater Runoff. Water Res. 2019, 154, 1–11 DOI: 10.1016/j.watres.2019.01.040.
https://www.sciencedirect.com/science/article/pii/S0043135419300946

Kral, A. E.; Pflug, N. C.; McFadden, M. E.; LeFevre, G. H.; Sivey, J. D.; Cwiertny, D. M. Photochemical Transformations of Dichloroacetamide Safeners. Environ. Sci. Technol. 2019, 53 (12), 6738–6746 DOI: 10.1021/acs.est.9b00861.
https://pubs.acs.org/doi/10.1021/acs.est.9b00861

Halaburka, B. J.; LeFevre, G. H.; Luthy, R. G. Quantifying the Temperature Dependence of Nitrate Reduction in Woodchip Bioreactors: Experimental and Modeled Results with Applied Case-Study. Environ. Sci. Water Res. Technol. 2019, 5, 782–797 DOI: 10.1039/C8EW00848E. https://pubs.rsc.org/en/content/articlehtml/2019/ew/c8ew00848e          

 Muerdter, C. P.; Wong, C. K.; LeFevre, G. H. Emerging Investigator Series: The Role of Vegetation in Bioretention for Stormwater Treatment in the Built Environment: Pollutant Removal, Hydrologic Function, and Ancillary Benefits. Environ. Sci. Water Res. Technol. 2018, 4 (5), 592–612 DOI: 10.1039/C7EW00511C. https://pubs.rsc.org/en/content/articlehtml/2018/ew/c7ew00511c 

Halaburka, B. J.; LeFevre, G. H.; Luthy, R. G. Evaluation of Mechanistic Models for Nitrate Removal in Woodchip Bioreactors. Environ. Sci. Technol. 2017, 51 (9), 5156–5164 DOI: 10.1021/acs.est.7b01025. https://pubs.acs.org/doi/abs/10.1021/acs.est.7b01025 

Klarich, K. L.; Pflug, N. C.; DeWald, E. M.; Hladik, M. L.; Kolpin, D. W.; Cwiertny, D. M.; LeFevre, G. H. Occurrence of Neonicotinoid Insecticides in Finished Drinking Water and Fate during Drinking Water Treatment. Environ. Sci. Technol. Lett. 2017, 4 (5), 168–173 DOI: 10.1021/acs.estlett.7b00081.https://pubs.acs.org/doi/abs/10.1021/acs.estlett.7b00081 

LeFevre, G. H.; Lipsky, A.; Hyland, K. C.; Blaine, A. C.; Higgins, C. P.; Luthy, R. G. Benzotriazole (BT) and BT Plant Metabolites in Crops Irrigated with Recycled Water. Environ. Sci. Water Res. Technol. 2017, 3 (2), 213–223 DOI: 10.1039/C6EW00270F. https://pubs.rsc.org/en/content/articlehtml/1976/ew/c6ew00270f 

Wolfand, J. M.; LeFevre, G. H.; Luthy, R. G. Metabolization and Degradation Kinetics of the Urban-Use Pesticide Fipronil by White Rot Fungus Trametes Versicolor. Environ. Sci. Process. Impacts 2016, 18 (10), 1256–1265 DOI: 10.1039/C6EM00344C. https://pubs.rsc.org/en/content/articlehtml/2016/em/c6em00344c 

LeFevre, G. H.; Portmann, A. C.; Müller, C. E.; Sattely, E. S.; Luthy, R. G. Plant Assimilation Kinetics and Metabolism of 2-Mercaptobenzothiazole Tire Rubber Vulcanizers by Arabidopsis. Environ. Sci. Technol. 2016, 50 (13), 6762–6771 DOI: 10.1021/acs.est.5b04716. https://pubs.acs.org/doi/abs/10.1021/acs.est.5b04716

Müller, C. E.; LeFevre, G. H.; Timofte, A. E.; Hussain, F. A.; Sattely, E. S.; Luthy, R. G. Competing Mechanisms for Perfluoroalkylacid Accumulation in Plants Revealed Using an Arabidopsis Model System. Environ. Toxicol. Chem. 2016, 35 (5), 1138–1147 DOI: DOI: 10.1002/etc.3251. https://onlinelibrary.wiley.com/doi/pdf/10.1002/etc.3251

LeFevre, G.; Paus, K.; Natarajan, P.; Gulliver, J.; Novak, P.; Hozalski, R. Review of Dissolved Pollutants in Urban Storm Water and Their Removal and Fate in Bioretention Cells. J. Environ. Eng. 2015, 141 (1), 4014050 DOI: 10.1061/(ASCE)EE.1943-7870.0000876. https://ascelibrary.org/doi/abs/10.1061/(ASCE)EE.1943-7870.0000876 

LeFevre, G. H.; Müller, C. E.; Li, R. J.; Luthy, R. G.; Sattely, E. S. Rapid Phytotransformation of Benzotriazole Generates Synthetic Tryptophan and Auxin Analogs in Arabidopsis. Environ. Sci. Technol. 2015, 49 (18), 10959–10968 DOI: 10.1021/acs.est.5b02749. https://pubs.acs.org/doi/abs/10.1021/acs.est.5b02749

Len MacGillivray

Rupasinghe, T. P., Hutchins, K. M., Bandaranayake, B. S., Ghorai, S., Karunatilake, C., Bucar, D. K., Swenson, D. C., Arnold, M. A., MacGillivray, L. R. and Tivanski, A. V. (2015). "Mechanical Properties of a Series of Macro- and Nanodimensional Organic Cocrystals Correlate with Atomic Polarizability." J Am Chem Soc 137(40): 12768-12771.

Timothy Mattes

Mattes, T., Jin, Y., Livermore, J., Pearl, M. and Liu, X. (2015). "Abundance and activity of vinyl chloride (VC)-oxidizing bacteria in a dilute groundwater VC plume biostimulated with oxygen and ethene." Applied Microbiology and Biotechnology: 1-10.

Eric Nuxoll

Worthington, K. S., Wiley, L. A., Mullins, R. F., Tucker, B. A. and Nuxoll, E. (2015). "Prevascularized silicon membranes for the enhancement of transport to implanted medical devices." Journal of Biomedical Materials Research Part B: Applied Biomaterials

Aliasger Salem

A. Do, R. Smith, P. Tobias, D. Carlsen, E. Pham, N.B. Bowden and A.K. Salem. Sustained Release of Hydrogen Sulfide (H2S) from Poly(lactic acid) Functionalized 4-hydroxythiobenzamide Microparticles to Protect against Oxidative Damage. Annals of Biomedical Engineering. 2019. In press. [CA][IF = 2.887]

T.M. Acri#, K. Shin#, D. Seol, N.Z. Laird, I. Song, S.M. Geary, J.L. Chakka, J. Martin, A.K. Salem. Tissue engineering for the temporomandibular joint. Advanced Healthcare Materials. 2019. [IF = 5.609]

T.L. Terry, B.E. Givens, V.G.J. Rodgers, A.K. Salem. Tunable properties of poly-DL-lactide-monomethoxypolyethylene glycol porous microparticles for sustained release of polyethylenimine-DNA polyplexes. AAPS PharmSciTech. 2019. [CA][IF = 2.451]

L. Amaral-Machado, W. Oliveira, E. Alencar, A.K. Cruz, H.A. Rocha, K. Ebeid, A.K. Salem, E. S.Egito. Bullfrog oil (Rana catesbeiana Shaw) induces apoptosis, in A2058 human melanoma cells by mitochondrial dysfunction triggered by oxidative stress. Biomedicine & Pharmacotherapy. 2019.

L. Hong, A. Akkouch, M. Zhu, M.R. Bustillos, S. Eliason, F. Qian, A.K. Salem, B.A. Amendt. MicroRNA-200c Attenuates Periodontitis by Modulating Proinflammatory and Osteoclastogenic Mediators. Stem Cells and Development. 2019

S.O. Suliman, E.I. Wafa, S.M. Geary, A.K. Salem. Polymeric particles as cancer vaccine vectors. American Pharmaceutical Review. 2019

J. L. Chakka, A.K. Salem. 3D Printing in Drug Delivery Systems. Journal of 3D Printing in Medicine. 2019. [CA][R]

A.K. Salem. Higher Education Institutions as a Fertile Environment for Inter-Disciplinary Research that Can Solve Complex Biological Problems. As Far as the Eye Can See: The Promises and Perils of Research and Scholarship in the 21st Century. 2019. (Edited by D. Reed; University of Iowa Press) [BC][LA][CA]

J.C. Quarterman, B.E. Givens, S.M. Geary, A.K. Salem. Drug Eluting Degradable Coatings on Biomedical Implants. Book Chapter in “Emerging Technologies for Biofabrication and Biomanufacturing”. (2019) Edited by El Assal, Chen and Demirci [CA][BC]

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018. [CA][IF = 38.99]

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018. [IF = 16.976]

J. Carter, E. Brown, J. Grace, A.K. Salem, E.E. Irish, N. Bowden Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137. PLoS One. 2018.

E.I. Wafa, S.M. Geary, K.A. Ross, J.T. Goodman, B. Narasimhan, A.K. Salem. A single shot of a polyanhydride particle-based vaccine generates potent antigen-specific anti-tumor immune responses in vivo. Journal of Pharmacology and Experimental Therapeutics. 2018. [CA][IF = 3.867]

K.S. Worthington, A. Do, B.A. Tucker and A.K. Salem. Two-Photon Polymerization as a Tool for Studying 3D Printed Topography-Induced Stem Cell Fate. Macromolecular Biosciences. 2018. [CA][IF = 3.392]

T. Kruger, B.E. Givens, T. Lansakara, K. Bell, H. Mohapatra, A.K. Salem, A. Tivanski, L. Stevens. Mechanosensitive endocytosis of high-stiffness, sub-micron microgels in macrophage and hepatocarcinoma cell lines. ACS Applied Bio Materials. 2018. [IF = TBD]

B. Khorsand#, S. Elangovan#*, L. Hong, M. Kormann, A.K. Salem. A Bioactive Collagen Membrane that Enhances Bone Regeneration. Journal of Biomedical Materials Research. 2018. [CA][IF = 2.308]

A. Do, K.S. Worthington, B.A. Tucker and A.K. Salem. Controlled Drug Delivery from 3D Printed Two-Photon Polymerized Poly(Ethylene Glycol) Dimethacrylate Devices. International Journal of Pharmaceutics. 2018. [CA][IF = 3.994]

R. Smith, W. Duan, J. Quaterman, A. Morris, C. Collie, M. Black, F. Toor,  A.K. Salem. Surface Modifying Doped Silicon Nanowire based Solar Cells for Applications in Bio-sensing. Advanced Technological Materials. 2018. [CA][IF = 4.662]

B.E. Givens, Y.W. Naguib, S.M. Geary, E.J. Devor, A.K. Salem. Nanoparticle-based delivery of CRISPR/Cas9 genome editing therapeutics. The AAPS Journal. 2018. [CA][IF = 3.819]

A. Do, S.M. Geary, D. Seol, P. Tobias, D. Carlsen, N. Leelakanok, J.A. Martin, A.K. Salem. Combining Ultrasound and Intratumoral Administration of Doxorubicin-loaded Microspheres to Enhance Tumor Cell Killing. International Journal of Pharmaceutics. 2018. [CA][IF = 3.994]

Nanoparticle-Based CpG-ODN Therapy for Treating Allergic Asthma. B.E. Givens, S.M. Geary and A.K. Salem. Immunotherapy. 2018. [CA][IF = 2.070]

N. Leelakanok, S.M. Geary, A.K. Salem. Antitumor Efficacy and Toxicity of 5-FU-loaded PLGA Pellets. Journal of Pharmaceutical Sciences. 2018. [CA][IF = 2.59]

N. Leelakanok, S.M. Geary, A.K. Salem. Fabrication and Use of PLGA-based Formulations Designed for Modified Release of 5-Fluorouracil. Journal of Pharmaceutical Sciences. 2018. [CA][IF = 2.59]

A. Do, R. Smith, T.M. Acri, S.M. Geary, A.K. Salem. 3D Printing Technologies for 3D Scaffold Engineering. Book Chapter in “Functional three-dimensional tissue engineering scaffolds: Technologies and applications”, (2018) Edited by Deng and Kuiper (Elsevier). [CA][BC]

B. Khorsand, N. Nicholson, A. Do, J.E. Femino, J.A. Martin, E. Petersen, B. Guetschow, D.C. Fredericks, A.K. Salem. Regeneration of bone using synergistic FGF2 and BMP2 gene delivery in a diaphyseal long bone radial defect diabetic rabbit model. Journal of Controlled Release. 2017. [CA][IF = 7.705]

A. Schumacher, C. Gilmer, K. Atluri, A. Jugessur, A.K. Salem, N. Bowden, M.L. Raghavan, D. Hasan. Development and Evaluation of a Nanometer-Scale Hemocompatible and Antithrombotic Coating Technology for Commercially Available Intracranial Stents and Flow Diverters. ACS Applied Nanomaterials. 2017.

A.S. Morris, A.K. Salem. Surface Engineered Nanoparticles: Considerations for Biomedical Applications. Advanced Engineering Materials. 2017. [R][CA]

K. Shin, T. Acri, S.M. Geary, A.K. Salem. Biomimetic Mineralization of Biomaterials Using Simulated Body Fluids (SBFs) for Bone Tissue Engineering and Regenerative Medicine. Tissue Engineering Part A. 2017. [R][CA][IF = 3.892]

A.K. Salem. Recent Advances in Musculoskeletal Tissue Regeneration. AAPS J. 2017. [R][LA][CA][IF = 3.819]

A.S. Morris, S.C. Sebag, J.D. Paschke, A. Wongrakpanich, K. Ebeid, M.E. Anderson, I.M. Grumbach and A.K. Salem. Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma. Molecular Pharmaceutics. 2017. [CA][IF = 4.342]

J. Srivastava, C.L Robertson, K. Ebeid, M. Dozmorov, D. Rajasekaran, R. Mendoza, A. Siddiq, M.A. Akiel, N. Jariwala, X. Shen, J.J. Windlw, M.A. Subler, N.D. Mukhopadhyay, S. Giashuddin, S. Ghosh, Z. Lai, Y. Chen, P.B. Fisher, A.K. Salem, A. Sanyal, D. Sarkar. A Novel Role of Astrocyte Elevated Gene-1 (AEG-1) in Regulating Non-alcoholic Steatohepatitis (NASH). Hepatology. 2017. [CA][IF = 11.055]

A. Wongrakpanich, A.S. Morris, S.M. Geary, M.L. Joiner, A.K. Salem. Surface-modified particles loaded with CaMKII inhibitor protect cardiac cells against mitochondrial injury. International Journal of Pharmaceutics. 2017. [CA][IF = 3.994]

E.I. Wafa, S.M. Geary, J.T. Goodman, B. Narasimhan, A.K. Salem. The Effect of Polyanhydride Chemistry in Particle-based Cancer Vaccines on the Magnitude of the Antitumor Immune Response. Acta Biomaterialia. 2017. [CA][IF = 6.025]

K.K. Ahmed, S.M. Geary, and A.K. Salem. Surface engineering tumor cells with adjuvant-loaded particles for use as cancer vaccines. Journal of Controlled Release. 2017. [CA][IF = 7.705]

B. Khorsand, S. Elangovan, L. Hong, A. Dewerth, M. Kormann, A.K. Salem. A comparative study of the bone regenerative effect of chemically modified RNA encoding BMP-2 or BMP-9. The AAPS Journal. 2017. [CA][IF = 3.819]

K. Ebeid, H. Giang, A.K. Salem. A HPLC-UV Method for Simultaneous Determination of MK-1775 and AZD-7762 in both Acetonitrile-Aqueous Solution and Mouse Plasma. Journal of Chromatography B. 2017. [CA][IF = 2.68]

S. D'Mello#, K. Atluri#, S.M Geary, L. Hong, S. Elangovan, A.K. Salem. Bone Regeneration using Gene-Activated Matrices. The AAPS Journal. 2016 #Joint First Authors [R][CA][IF = 3.819]

A.B. Plonka, B. Khorsand, N. Yu, J.V. Sugai, A.K. Salem, W.V. Giannobile, S. Elangovan. Effect of Sustained PDGF Non-Viral Gene Delivery on Repair of Tooth-Supporting Bone Defects.  Gene Therapy. 2016 [IF = 3.242]

T. Sharp, B. Khorsand, C. Fischer, S. Eliason , A.K. Salem, K. Brogden, B. Amendt, L. Hong. MicroRNA-200c directly targets and represses IL-6, IL-8, and CCL-5 expression and enhances osteogenic differentiation. PLoS One. 2016. [IF = 3.057]

K. Atluri, A. De Jesus, S. Chinnathambi, M. Brouillette, J. Martin, A.K. Salem*, E. Sander*. Blebbistatin-Loaded Poly(D,L lactide-co-glycolide) Particles for Treating Arthrofibrosis. ACS Biomaterials Science & Engineering. 2016. [CA][IF = pending]

K.S. Worthington, B.J. Green, M. Rethwisch, L.A. Wiley, B.A. Tucker, and C.A.Guymon and A.K. Salem. Neuronal Differentiation of Induced Pluripotent Stem Cells on Surfactant Templated Chitosan Hydrogels. Biomacromolecules. 2016. [CA][IF = 5.75]

A. Do, A. Akkouch, B. Green, S.M. Geary, I. Ozbolat, A.K. Salem. Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes. Annals of Biomedical Engineering. 2016. [CA][IF = 2.887]

S.M. Geary, A.S. Morris and A.K. Salem. Assessing the Impact of Engineered Nanomaterials on the Environment and Human Health. Journal of Allergy and Clinical Immunology. 2016. [CA][R][IF = 12.485]

K. Atluri, J. Lee, D. Seabold, S. Elangovan, A.K. Salem. Gene Activated Titanium Surfaces Promote In Vitro Osteogenesis. The International Journal of Oral & Maxillofacial Implants. 2016. [CA][IF = 1.451]

A. Wongrakpanich, I.A. Mudunkotuwa, S.M. Geary, A.S. Morris, K.A. Mapuskar, D.R. Spitz, V.H. Grassian and A.K. Salem. Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells. Environmental Science: Nano. 2016. [CA][IF = 5.896]

S. Elangovan, M.S.D. Kormann, B. Khorsand, A.K. Salem.  The Oral and Craniofacial Relevance of Chemically Modified RNA Therapeutics. Discovery Medicine. 2016. [CA][R][IF = 3.426]

K.S. Worthington, L.A. Wiley, A. Guymon, A.K. Salem and B.A. Tucker. Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous PLGA Scaffolds.  Journal of Ocular Pharmacology and Therapeutics. 2016. [CA][IF = 1.754 ]

K. Ahmed, S.M. Geary, A.K. Salem. Development and Evaluation of Biodegradable Particles Co-loaded with Antigen and the Toll-like Receptor Agonist, Pentaerythritol Lipid A, as a Cancer Vaccine. Journal of Pharmaceutical Sciences. 2016. [CA][IF = 2.59]

Nanotoxicity. A.S. Morris, A.K. Salem. Nanomedicine for Inflammatory Diseases.  (CRS Press, Taylor and Francis; Ed: L. Milane, M. Amiji). 2016. [CA][BC]

Production of adjuvant-loaded biodegradable particles for use in cancer vaccines. C.M. de Barros, E.I. Wafa, K. Chitphet, K. Ahmed, S.M. Geary, A.K. Salem. Vaccine Adjuvants: Methods and Protocols (Springer; Ed: C.B. Fox). 2016. [CA][BC]

A.S. Morris, A. Adamcakova-Dodd, S.E. Lehman, A. Wongrakpanich, P.S. Thorne, S.C. Larsen, A.K. Salem. Amine Modification of Nonporous Silica Nanoparticles Reduces Inflammatory Response Following Intratracheal Instillation in Murine Lungs. Toxicology Letters. 2015. [CA][IF = 3.262]

S.E. Lehman, A.S. Morris, P.S. Mueller, A.K. Salem, V.H. Grassian, S.C. Larsen. Silica Nanoparticle-Generated ROS as a Predictor of Cellular Toxicity: Mechanistic Insights and Safety by Design. Environmental Science: Nano. 2015. [IF = 5.896]

S. Elangovan*, B. Khorsand*, A. Do, L. Hong, A. Dewerth, M. Kormann, R.D. Ross, D.R. Sumner, C. Allamargot, and A.K. Salem. Chemically modified RNA activated matrix induced bone regeneration. Journal of Controlled Release. 2015. [CA][IF = 7.705]

N. Leelakanok, C.L Fischer, A.M. Bates, J.M. Guthmiller, G.K. Johnson, A.K. Salem, K.A. Brogden, N. Brogden Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions. Toxicology Letters. 2015. [CA][IF = 3.262]

S.R. D’Mello, S. Elangovan, A.K. Salem. FGF2 Gene Activated Matrices Promote Proliferation of Bone Marrow Stromal Cells. Archives of Oral Biology. 2015. [CA][IF = 1.549]

S.M. Geary, Q. Hu, V.B. Joshi, N.B. Bowden, A.K. Salem. Diaminosulfide based polymer microparticles as cancer vaccine delivery systems.  Journal of Controlled Release. 2015. [CA][IF = 7.705]

T.S. Long, A. Wongrakpanich, A. Do, A.K. Salem, N.B. Bowden. Long-term release of a thiobenzamide from a backbone functionalized poly(lactic acid). Polymer Chemistry. 2015. [IF = 5.687]

K.A. Ross, T.M. Brenza, A. Binnebose, Y. Phanse, A. Kanthasamy, H.Gendelman, A.K. Salem, L. Bartholomay, B. Bellaire, B. Narasimhan. Nano-enabled Delivery of Diverse Payloads across Complex Biological Barriers. Journal of Controlled Release. 2015. [R][IF = 7.705]

A. Wongrakpanich, M. Wu and A.K. Salem. Correlating Intracellular Non-viral Polyplex Localization with Transfection Efficiency using High-Content Screening. Biotechnology Progress. 2015. [CA] [IF = 2.167]

K. Atluri, D. Seabold, L. Hong, S. Elangovan, A.K. Salem. Nanoplex-Mediated Co-delivery of Fibroblast Growth Factor and Bone Morphogenetic Protein Genes Promotes Osteogenesis in Human Adipocyte-Derived Mesenchymal Stem Cells. Molecular Pharmaceutics. 2015. [CA][IF = 4.342]

D. Rajasekaran#, J. Srivastava#, K. Ebeid#, R. Gredler, M. Akiel, N. Jariwala, C. L. Robertson, X. Shen, A. Siddiq, P.B. Fisher, A.K. Salem*, D. Sarkar*. Combination of nanoparticle-delivered siRNA for Astrocyte elevated gene-1 (AEG-1) and all-trans retinoic acid (ATRA): an effective therapeutic strategy for hepatocellular carcinoma (HCC). Bioconjugate Chemistry. 2015 #Joint First Authors *Corresponding Authors. [CA][IF = 4.500]

A. Do, B. Khorsand, S.M. Geary, A.K. Salem. 3D Printing of Scaffolds for Tissue Regeneration Applications. Advanced Healthcare Materials. 2015. [CA][R][IF = 5.79]

M. Flores, C. Chew, K. Tyan, W.Q. Huang, A.K. Salem and R. Clynes. FcγRIIB Prevents Inflammatory Type I IFN Production from Plasmacytoid Dendritic Cells during a Viral Memory Response. Journal of Immunology. 2015. [IF = 4.92]

A. Makkouk, V.B Joshi, C.D. Lemke, A. Wongrakpanich, A.K Olivier, S.E. Blackwell, A.K. Salem, G.J. Weiner. Three Steps to Breaking Tolerance to Lymphoma: A Microparticle Approach. Cancer Immunology Research. 2015. [IF = 3.57]

A. Makkouk, V.B. Joshi, A. Wongrakpanich, C.D. Lemke, B.P. Gross, A.K. Salem, G.J. Weiner. Biodegradable Microparticles Loaded with Doxorubicin and CpG for In Situ Immunization Against Tumors. The AAPS Journal. 2015. [IF = 3.819]

A.K. Salem. Nanoparticles in Vaccine Delivery. The AAPS Journal. 2015. [CA][R][IF = 3.819]

S.R. D’Mello, S. Elangovan, L. Hong, R.D. Ross, D.R. Sumner, and A.K. Salem. A Pilot Study Evaluating Combinatorial and Simultaneous Delivery of Polyethylenimine-Plasmid DNA Complexes Encoding for VEGF and PDGF for Bone Regeneration in Calvarial Bone Defects. Current Pharmaceutical Biotechnology. 2015. [CA][IF = 2.511]

Michael Schnieders

Booth, K. T., Azaiez, H., Kahrizi, K., Simpson, A. C., Tollefson, W. T. A., Sloan, C. M., Meyer, N. C., Babanejad, M., Ardalani, F., Arzhangi, S., Schnieders, M. J., Najmabadi, H. and Smith, R. J. H. (2015). "PDZD7 and hearing loss: More than just a modifier." American Journal of Medical Genetics Part A:

DeLuca, A. P., Whitmore, S. S., Barnes, J., Sharma, T. P., Westfall, T. A., Scott, C. A., Weed, M. C., Wiley, J. S., Wiley, L. A., Johnston, R. M., Schnieders, M. J., Lentz, S. R., Tucker, B. A., Mullins, R. F., Scheetz, T. E., Stone, E. M. and Slusarski, D. C. (2015). "Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis." Hum Mol Genet.

Stephen D. LuCore, J. M. L., Kyle T. Powers, Shibo Gao, Ava M. Lynn, William T.A. Tollefson, Timothy D. Fenn, M. Todd Washington, Michael J. Schnieders (2015). "Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures." Biophysical Journal 109(4): 816-826.

Jerry Schnoor

Schwab, F., Zhai, G., Kern, M., Turner, A., Schnoor, J. L. and Wiesner, M. R. (2015). "Barriers, pathways and processes for uptake, translocation and accumulation of nanomaterials in plants - Critical review." Nanotoxicology: 1-22.

Bircher, S., Card, M. L., Zhai, G., Chin, Y.-P. and Schnoor, J. L. (2015). "Sorption, uptake and biotransformation of 17β-estradiol, 17α-ethinylestradiol, zeranol and trenbolone acetate by hybrid poplar." Environmental Toxicology and Chemistry.

David Soll

Pujol, C., Daniels, K. J. and Soll, D. R. (2015). "A Comparison of Switching and Biofilm Formation Between MTL-homozygous Strains of Candida albicans and Candida dubliniensis." Eukaryot Cell.

Wessels, D. J., Lusche, D. F., Kuhl, S., Scherer, A., Voss, E. and Soll, D. R. (2016). "Quantitative Motion Analysis in Two and Three Dimensions." Methods Mol Biol 1365: 265-292.

Timothy Yahr

Jorth, P., Staudinger, B. J., Wu, X., Hisert, K. B., Hayden, H., Garudathri, J., Harding, C. L., Radey, M. C., Rezayat, A., Bautista, G., Berrington, W. R., Goddard, A. F., Zheng, C., Angermeyer, A., Brittnacher, M. J., Kitzman, J., Shendure, J., Fligner, C. L., Mittler, J., Aitken, M. L., Manoil, C., Bruce, J. E., Yahr, T. L. and Singh, P. K. (2015). "Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs." Cell Host Microbe 18(3): 307-319.

Todd Washington 

Stephen D. LuCore, J. M. L., Kyle T. Powers, Shibo Gao, Ava M. Lynn, William T.A. Tollefson, Timothy D. Fenn, M. Todd Washington, Michael J. Schnieders (2015). "Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures." Biophysical Journal 109(4): 816-826.