DEPT: Medicinal and Natural Products Chemistry
YEAR OF GRAD STUDY: 2005-2011
MENTOR(S): Dr. Jonathan Doorn
SOURCE(S) OF SUPPORT: MNPC department, CBB, American Foundation for Pharmaceutical Educ.
University of Iowa Ph.D. 2011 Medicinal and Natural Products Chemistry
Elmhurst College B.S. 2005Chemistry
2011 Central States Society of Toxicology Conference Outstanding Student Poster Award
2010 University of Iowa Graduate Student Senate Travel Fund Scholarship
2009 University of Iowa Graduate Student Senate Travel Fund Scholarship
2009 University of Iowa Student Government Scholarly Presentation Award
2006-2009 University of Iowa Center for Biocatalysis and Bioprocessing Fellow
2008-2009 American Foundation for Pharmaceutical Education Pre- Doctoral Endowed Fellowship in Pharmaceutical Science
2008 University of Iowa Graduate Student Senate Travel Fund Scholarship
2008 University of Iowa Student Government Scholarly Presentation Award
2007 The Ernest Mario Endowed - American Foundation for Pharmaceutical Education Pre-Doctoral Fellowship in Pharmaceutical Science
2007 University of Iowa Graduate Student Senate Travel Fund Scholarship
2007 University of Iowa Student Government Scholarly Presentation Award
2005-2006 Medicinal and Natural Products Chemistry Division Fellow
Sep 2013 to Jun 2015 Visiting Assistant Professor of Chemistry, North Central College, Naperville, IL
Jun 2014 to Aug 2014 Lecturer of Chemistry, Benedictine University, Lisle, IL
Aug 2011 to May 2013 Adjunct Assistant Professor of Chemistry and Adjunct Assistant Professor of Kinesiology
RESEARCH EXPERIENCE (prior to entering program):
Jun 2004 to June 2005 Research and Development Laboratory Technician, Loparex, Inc., Willowbrook, IL
May 2004 to Aug 2004 Research and Development Intern, Jel-Sert Co., West Chicago, IL
Jun 2003 to Aug 2003 Student Research Assistant, Department of Chemistry, Elmhurst College, Elmhurst, IL
CURRENT RESEARCH ACTIVITIES (brief description):
I currently work as a full time research chemist in the Small Molecule Chemistry Research and Development Department at Integrated DNA Technologies, Inc. in Coralville, IA. My efforts are focused on oligonucleotide synthesis and derivation.
COURSES TAKEN (this graduate program):
APPLICATION(S) FOR POSTDOCTORAL FUNDING (BUT THIS PROGRAM):
PUBLICATIONS: PLEASE LIST BELOW AND CONTINUE ON THE BACK OF THIS FORM:
Anderson, D.G., Mariappan, S.V.S., Buettner, G.R., Doorn, J.A. (2011) Oxidation of 3,4-Dihydroxyphenylacetaldehyde, A Toxic Intermediate of Dopamine Metabolism, to a Semi-Quinone Radical and an ortho-Quinone. J Biol Chem 286, 26978-26986.
Jinsmaa Y., Florang V.R., Rees J.N., Mexas L.M., Eckert L.L., Allen E.M., Anderson D.G., Doorn J.A. (2011) Dopamine-derived biological reactive intermediates and protein modifications: Implications for Parkinson’s disease. Chem Biol Interact 192(1-2):118-21.
Allen, M.G., Anderson, D.G., Florang, V.R., Khanna, M., Hurley, T.D., Doorn, J.A. (2010) Relative Inhibitory Potency of Molinate and Metabolites with Aldehyde Dehydrogenase 2: Implications for the Mechanism of Enzyme Inhibition. Chem Res Toxicol 23, 1843-50.
Chemburkar, S.J., Anderson, D.G., Reddy, R.E. (2010) Efficient Method for Synthesis of 2-Acetylbenzo(b)thiophene and is Derivatives, The Key Synthons for 5-Lipoxygenase Inhibitors. Synth Comm 40, 1887-1894.
Jinsmaa, Y., Florang, V.F., Rees, J.N., Anderson, D.G., Strack, S., Doorn, J.A. (2009) Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. Chem Res Toxicol. 22, 835-41.
Rees, J.N, Florang, V.F., Anderson, D.G., and Doorn, J.A. (2007) Lipid peroxidation products inhibit dopamine catabolism yielding aberrant levels of a reactive intermediate. Chem Res Toxicol. 20, 1536-42.
Florang, V.F., Rees, J.R., Brogden, N.K., Anderson, D.G., Hurley, T.D., and Doorn, J.A. (2007) Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. Neurotoxicology. 28, 76-82.
Doorn, J.A., Florang, V.F, Rees, J.N., Anderson, D.G., Brogden, N.K. (2006) Impairment in oxidative biotransformation of a reactive intermediate of dopamine metabolism. Neurotoxicology. 27, 1189-1190.
Florang, V.F., Rees, J.R., Brogden, N.K., Anderson, D.G., Hurley, T.D., and Doorn, J.A. (2006) Inhibition of Mitochondrial Aldehyde Dehydrogenase-Mediated Oxidation of 3,4-dihydroxyphenylacetaldehyde. In Enzymology and Molecular Biology of Carbonyl Metabolism; Weiner, H., Eds.; Purdue University Press: West Lafayette, IN, 2006; Volume 13, 33-39.