YEAR OF GRAD STUDY: Completed 2011
MENTOR(S): Rob Kerns
SOURCE(S) OF SUPPORT: TA, NIH Fellowship, College of Pharmacy Fellowship
University of Texas at Austin BS 2003 Chemistry
University of Iowa PhD 2011 Pharmacy - MNPC
Academic Honors (Spring 2003),
US Air Force Meritorious Achievement (2006),
NIH Fellowship (2007)
TEACHING EXPERIENCE: None
RESEARCH EXPERIENCE (prior to entering program):
US Air Force Research Laboratory, Wright Patterson AFB: Sensors Directorate, Electro-optics Branch. Designed and oversaw efforts at miniaturization of analytical laboratory equipment for field portable chemical weapons detection systems. 2003-2006
CURRENT RESEARCH ACTIVITIES (brief description):
Design and optimization of methods of modifying DNA oligos; creation of new fluorescent dyes and quenchers for assays and clinical uses; improvement of methods of solid phase DNA synthesis; improvement of PCR and RT-PCR by various methods 2009-present
POSTDOCTORAL TRAINING APPLIED FOR, UNDERWAY, OR COMPLETED: None
APPLICATION(S) FOR FUNDING (BUT THIS PROGRAM): None
Mustaev, Arkady; Malik, Muhammad; Zhao, Xilin; Kurepina, Natalia; Luan, Gan; Oppegard, Lisa M.; Hiasa, Hiroshi; Marks, Kevin R.; Kerns, Robert J.; Berger, James M. (2014) Fluoroquinolone-Gyrase-DNA Complexes. Journal of Biological Chemistry. 289(18), pp 12300-12312.
Marks, Kevin Randall. Investigating the fluoroquinolone-topoisomerase interaction by use of novel fluoroquinolones and quinazoline analogs. Dissertation, 2011.
Malik, Muhammad; Marks, Kevin R.; Mustaev, Arkady; Zhao, Xilin; Chavda, Kalyan; Kerns, Robert J.; Drlica, Karl. Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutated strains of Mycobacterium smegmatis. (2011) Antimicrobial Agents and Chemotherapy, 55(5), pp 2335-2343.
Marks, Kevin R.; Malik, Muhammad; Mustaev, Arkady; Hiasa, Hiroshi; Drlica, Karl; Kerns, Robert J. Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones. (2011) Bioorganic & Medicinal Chemistry Letters, 21(15), pp 4585-4588.
Malik, Muhammad; Marks, Kevin R.; Schwanz, Heidi A.; German, Nadezhda; Drlica, Karl; Kerns, Robert J. Effect of N-1/C-8 ring fusion and C-7 ring structure on fluoroquinolone lethality. (2010) Antimicrobial Agents and Chemotherapy, 54(12) pp 5214-5221