DEPT: Radiation Oncology (Free Radical and Radiation Biology Program
YEAR OF GRAD STUDY: 5th
MENTOR(S): Michael Schultz, PhD
SOURCE(S) OF SUPPORT:
The Free Radical and Radiation Biology 2013-2014 Program NIH T32 Training Grant Pre-Doctoral Fellowship Award (University of Iowa, 2013-2014)
The Center for Biocatalysis and Bioprocessing NIH T32 Training Grant Pre-Doctoral Fellowship Award (University of Iowa, 2011-2013)
Holden Comprehensive Cancer Center (University of Iowa)
EDUCATION:
University of Wisconsin-Platteville B.S. May 2010 Biology/Biotechnology minor
University of Iowa Ph.D. Dec. 2015 Free Radical and Radiation Biology
HONORS:
Research Internships in Science and Engineering (RISE) in India Fellowship Award (Indo-US Science and Technology Forum, 2013)
Graduate Student Senate (GSS) Travel Funds Award (University of Iowa, 2014)
Graduate & Professional Student Government Grant Award (University of Iowa, 2014)
Research Foundation Ventures and Licensing Inventor Award (University of Iowa, 2014)
Research Foundation Ventures and Licensing Inventor Award (University of Iowa, 2012)
TEACHING EXPERIENCE:
Lecturer, 2013-2014. Topics: LET, RBE, Molecular Effects, Acute Radiation Syndrome and Modification of Cell and Tissue Responses to Radiation, Course: Radiation Safety and Radiobiology, Carver College of Medicine (Radiation Sciences Program), University of Iowa, Iowa City, IA
RESEARCH EXPERIENCE (prior to entering program): N/A
CURRENT RESEARCH ACTIVITIES (brief description):
The development of mitochondria-targeted small molecules for the imaging and therapy of metastatic melanoma.
COURSES TAKEN (this graduate program):
Drug Discovery and Mechanisms
Introduction to Biocatalysis
Fundamentals of Gene Expression
Fundamentals of Dynamic Cell Processes
POSTDOCTORAL TRAINING APPLIED FOR: N/A
APPLICATION(S) FOR POSTDOCTORAL FUNDING: N/A
PUBLICATIONS:
Kloepping KC, Kraus AS, Hedlund DK, Gnade CM, Seol DR, Fath MA, Pigge FC, Spitz DR, and Schultz MK. Triphenylphosphonium-based compounds inhibit mitochondria metabolism and slow melanoma tumor growth when administered via a thermosensitive hydrogel-based delivery system. (manuscript in preparation)
Martin ME, O'Dorisio MS, Kloepping KC, Walsh S, Leverich W, and Schultz MK. (2013). “Click” cyclized gallium-68 labeled peptides for molecular imaging and therapy: synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system. Recent Results Cancer Res 194: 149-175
Baumhover NJ, Martin ME, Parameswarappa SG, Kloepping KC, O'Dorisio MS, Pigge FC, Schultz MK. (2011). Improved synthesis and biological evaluation of chelator-modified alpha-MSH analogs prepared by copper-free click chemistry. Bioorganic & medicinal chemistry letters 21(19): 5757-5761
Rockey WM, Huang L, Kloepping KC, Baumhover NJ, Giangrande PH, Schultz MK. (2011). Synthesis and radiolabeling of chelator-RNA aptamer bioconjugates with copper-64 for targeted molecular imaging. Bioorg Med Chem 19(13): 4080-4090