29th Annual CBB Conference
"Expanding the Frontiers in Biocatalytic Science"
October 22, 2022
The University of Iowa
Pharmacy Building, Iowa City, IA
Saturday, October 22, 2022 – Pharmacy Building, 180 South Grand Avenue
7:30 – 8:15 am—Registration – CPB Atrium
7:30 – 8:15—Continental Breakfast – CPB Atrium
8:15 – 8:30—Program-210 CPB
Introduction and welcome:
Mark A. Arnold, Ph.D., Director, Center for Biocatalysis and Bioprocessing; Edwin B. Green Chair Professor in Laser Chemistry, Department of Chemistry, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA
Aliasger Salem, Ph.D., Lyle and Sharon Bighley Chair in Pharmaceutical Science, College of Pharmacy; Associate Vice President for Research, University of Iowa, Iowa City, IA
8:30 – 9:15—MAPPING THE ROLE OF UNdERSTUDIED UBIQUITIN-LIKE PROTEINS IN INFECTION AND DISEASE
Lilliana Radoshevich,Ph.D., Assistant Professor of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA
9:15 – 10:00—Challenges and Opportunities in Process Analytical Technologies (PAT) for Biomanufacturing
Nigel F. Reuel, Ph.D., Associate Professor of Chemical and Biological Engineering, Iowa State University of Science and Technology, Ames, IA
10:00 – 10:15—Break-CPB110 Atrium
10:15 – 11:00—Computational Molecular Design in Plant Biotechnology at Bayer Crop Science
Christina Taylor, Ph.D., Computational Protein Design Lead and Science Fellow, Bayer Crop Science, St. Louis, MO
11:00 – 11:45—Targeting Fibroblast Activation Protein Alpha as a Robust Biomarker in Glioma
Thaddeus J. Wadas, Ph.D., Associate Professor of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA
11:45 – 12:00 pm—Relocation to CPB Atrium
12:00 – 12:45—Lunch- poster session 1 (odd numbers)
12:45 – 1:30—Lunch- poster session 2 (even numbers)
Afternoon Session – 210 CPB
1:45 – 2:30—An overview of IDT’s enzyme engineering and genome editing nuclease content
Christopher A. Vakulskas, Ph.D., Senior Director of Enzyme Evolution, Integrated DNA Technologies, Inc., Coralville, IA
2:30 – 3:30— NIH/CBB Fellow Presentations
Therapeutic Disruption of RAD52-DNA Complexation via Novel Drug-Like Inhibitors for the Treatment of BRCA2 Deficient Cancers
Divya Bhat, Ph.D. Candidate, Maria Spies Research Group, Department of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA
PROBING THE INVOLVEMENT OF DISTAL RESIDUES IN ACTIVE SITE DYNAMICS OF PURINE NUCLEOSIDE PHOSPHORYLASE
Nicholas A. Luedtke, Ph.D., Candidate, Christopher M. Cheatum Research Group, Department of Chemistry, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA
Fork-remodeling helicase Rad5 preferentially reverses replication forks with gaps in the leading strand
Justin Ling, Ph.D. Candidate, M. Todd Washington Research Group, Department of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA
3:30—Awards and Closing Remarks
3:45—Adjourn