29th Annual CBB Conference
"Expanding the Frontiers in Biocatalytic Science" 

October 22, 2022
The University of Iowa 
Pharmacy Building, Iowa City, IA

Saturday, October 22, 2022 – Pharmacy Building, 180 South Grand Avenue

7:30 – 8:15 am—Registration –  CPB Atrium

7:30 – 8:15—Continental Breakfast – CPB Atrium

8:15 – 8:30—Program-210 CPB

Introduction and welcome:

Mark A. Arnold, Ph.D., Director, Center for Biocatalysis and Bioprocessing; Edwin B. Green Chair Professor in Laser Chemistry, Department of Chemistry, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA                         

                              Aliasger Salem, Ph.D., Lyle and Sharon Bighley Chair in Pharmaceutical Science, College of                                    Pharmacy; Associate Vice President for Research, University of  Iowa, Iowa City, IA

 

8:30 – 9:15—MAPPING THE ROLE OF UNdERSTUDIED UBIQUITIN-LIKE PROTEINS IN INFECTION AND                                   DISEASE

    Lilliana Radoshevich,Ph.D.,  Assistant Professor of Microbiology and Immunology, Carver               College of Medicine, University of Iowa, Iowa City, IA

9:15 – 10:00—Challenges and Opportunities in Process Analytical Technologies (PAT) for                                 Biomanufacturing

      Nigel F. Reuel, Ph.D., Associate Professor of Chemical and Biological Engineering, Iowa State            University of Science and Technology, Ames, IA

10:00 – 10:15—Break-CPB110 Atrium

10:15 – 11:00—Computational Molecular Design in Plant Biotechnology at Bayer Crop                                        Science

       Christina Taylor, Ph.D., Computational Protein Design Lead and Science Fellow, Bayer Crop              Science, St. Louis, MO

11:00 – 11:45—Targeting Fibroblast Activation Protein Alpha as a Robust Biomarker in                                         Glioma

       Thaddeus J. Wadas, Ph.D., Associate Professor of Radiology, Carver College of                                     Medicine, University of Iowa, Iowa City, IA

11:45 – 12:00 pm—Relocation to CPB Atrium                 

12:00 – 12:45—Lunch- poster session 1 (odd numbers)

12:45 –  1:30—Lunch- poster session 2 (even numbers)

Afternoon Session – 210 CPB

1:45  –  2:30—An overview of IDT’s enzyme engineering and genome editing nuclease content

    Christopher A. Vakulskas, Ph.D., Senior Director of Enzyme Evolution, Integrated DNA                     Technologies, Inc., Coralville, IA

2:30 – 3:30— NIH/CBB Fellow Presentations

                       Therapeutic Disruption of RAD52-DNA Complexation via Novel Drug-Like                                            Inhibitors for the Treatment of BRCA2 Deficient Cancers

                      Divya Bhat, Ph.D. Candidate, Maria Spies Research Group, Department of Biochemistry and                                Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA

                      PROBING THE INVOLVEMENT OF DISTAL RESIDUES IN ACTIVE SITE DYNAMICS OF PURINE                                NUCLEOSIDE PHOSPHORYLASE

                      Nicholas A. Luedtke, Ph.D., Candidate, Christopher M. Cheatum Research Group, Department                          of Chemistry, College of Liberal Arts and Sciences, University of  Iowa, Iowa City, IA

                     Fork-remodeling helicase Rad5 preferentially reverses replication forks with                           gaps in the leading strand

                     Justin Ling, Ph.D. Candidate, M. Todd Washington Research Group, Department of Biochemistry                      and Molecular Biology, Carver College of Medicine, University  of Iowa, Iowa City, IA

3:30—Awards and Closing Remarks

3:45—Adjourn