Welcome to CBB

The Center for Biocatalysis and Bioprocessing (CBB) is a microbial biomanufacturing and research facility that bridges the gap between laboratory discovery and commercial-scale bioprocessing solutions. Located at the University of Iowa, CBB offers microbial fermentation, recombinant protein expression, and downstream protein purification services for a wide variety of clients, including international corporations and early-stage start-up companies. For clients interested in clinical applications, a cGMP suite is available to manufacture of proteins under the quality standards defined by the U.S. Food and Drug Administration specifically for Phase 1 clinical trials.  

 

By combining the technical capabilities of a university-based pilot-scale CDMO with the expertise of affiliated faculty and researchers, the CBB serves as a trusted partner to biotech startups, vendors for the life science community, pharmaceutical companies, and academic innovators. Our facility supports innovation across multiple sectors, supporting the development and scale-up of protein-based therapeutics, specialty enzymes, reagent proteins, and other next-generation biologics. In addition, CBB plays a key role in bioprocessing workforce development through graduate training and NIH-funded biomanufacturing fellowships, thereby helping to shape the future of the biotech and life sciences industries.  

We Work with a Wide Range of Clients across the Biotech, Life Sciences, and Pharmaceutical Spaces

We welcome clients from diverse industry sectors, including biotech startups seeking scalable biomanufacturing, academic research laboratories advancing translational science, life science vendors supporting basic and applied research worldwide, as well as large multinational pharmaceutical manufacturers and government agencies involved in drug development and public health initiatives. Our services are accessible to clients regardless of geographic location, ensuring professional support for protein production, purification, and bioprocess development. 

How to Start a Service with CBB?

We’re here to support your project every step of the way. Getting started with the Center for Biocatalysis and Bioprocessing (CBB) is simple. Clients can request services by completing our Client Request Form online. After submitting the form, a CBB representative will contact you within 2-3 business days to confirm your request and to schedule an initial consultation.  

 

During this initial consultation, your project requirements will be discussed in a non-confidential manner. CBB will then evaluate whether our facility can meet your specific needs. If so, a Confidential Disclosure Agreement (CDA) template will be provided for your consideration. In parallel, we will share a ballpark estimate of the costs for your project.  
 
Upon execution of the CDA, a more in-depth discussion will be used to provide a more accurate assessment of the costs for CBB’s bioprocessing services. Services can begin once a Master Service Agreement is in place and a Project Ordered is created specifically tailored toward your bioprocessing needs.  
 
Our team will be with you through every step to ensure a smooth and compliant bioprocessing experience.  

Bioprocessing Services

Fermentation, protein purification, & cGMP production for Phase-1 clinical trials

Academic Opportunities

Predoctoral Iowa Biotech Fellowship, CBB & NIH fellowships available

Annual Conference

The CBB hosts an annual conference focusing on innovations in the biocatalytic sciences.

"I worked for CBB since they first started with fermentation in their present location! I had previous experiences running 2000 liter fermenters at Solvay Animal Health. I really enjoyed watching the fermenters being delivered and set up. I worked closely with B. Braun company getting them up and running. The team came together over the next couple years. They have all become very experienced operators in the upstream and downstream processing! Everyone works well together and produces high quality product! I have since retired and miss my coworkers."

CBB Operator Working in the Lab

30 +

Years of Manufacturing Experience
CBB Operator Working in the Lab

265 +

Fellowships Awarded to Students
CBB Operator Working in the Lab

55 +

Associated UI Faculty

News

Maria Spies, Ph.D.

Saturday, November 15, 2025

Tyler J. Woodward

Wednesday, October 15, 2025

Hossein Zare

Wednesday, October 15, 2025

Reza Nejadnik

Wednesday, October 15, 2025

Meet Some of Our Associated Faculty

Office of VP for Research Events

Iowa City International Documentary Film Festival promotional image

Iowa City International Documentary Film Festival

Thursday, April 23 to Sunday, April 26, 2026 (all day)
Adler Journalism and Mass Communication Building
The Iowa City International Film Festival is a student-run experimental film festival hosted in Iowa City.

Spring 2026 IRB Office Hours

Thursday, April 23, 2026 10:00am to 12:00pm
Virtual
IRB Office Hours are for all UI faculty, staff, and Investigators, HawkIRB delegates, and research team members involved with Human Subjects research.

College of Medicine Events

Biochemistry and Molecular Biology Seminar: Dr. Cynthia Nau Cornelissen promotional image

Biochemistry and Molecular Biology Seminar: Dr. Cynthia Nau Cornelissen

Thursday, April 23, 2026 10:30am to 11:20am
Medical Education Research Facility

This event is open to the public.

Urgent threat Neisseria gonorrhoeae utilizes human-specific protein receptors to overcome nutritional immunity

Cynthia Nau Cornelissen, PhD
Georgia State Washington

https://biomedical.gsu.edu/profile/cynthia-nau-cornelissen/

Faculty Co-Hosts: Miles Pufall, PhD and Jessica Tucker, PhD

Internal Medicine Grand Rounds 4/23/2026

Thursday, April 23, 2026 12:00pm to 1:00pm
General Hospital

Raynaud Phenomenon! Or is It? The differential, diagnosis and management of red, white and blue color changes in the fingers and toes
Robyn Domsic, MD, MPH, University of Pittsburgh

College of Pharmacy Events

College of Pharmacy PSET Seminar Series: Robin Bogner, PhD promotional image

College of Pharmacy PSET Seminar Series: Robin Bogner, PhD

Tuesday, April 28, 2026 11:30am
College of Pharmacy Building

The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET) in the College of Pharmacy will host a seminar presented by: 

Robin Bogner, PhD
Director, Kildsig Center for Pharmaceutical Processing Research (CPPR)
Department of Pharmaceutical Sciences
University of Connecticut
Storrs, Connecticut

Seminar Title: "Emerging Technology to Enhance the Stabilization of Therapeutics by Lyophilization"

All are welcome to attend. No pre-registration required.

Celebrating International Student Success promotional image

Celebrating International Student Success

Friday, May 1, 2026 3:00pm to 5:00pm
ReUnion Brewery
International students and scholars are invited to join International Programs for a celebration of community and achievement, coming together to reflect on and recognize the accomplishments of this academic year!