What has been termed the “12 Principles of Green Chemistry” should be extended to cover a pivotal aspect relevant to green chemistry when it comes to developing novel processes to make biobased chemicals and can be conveniently condensed into one overarching principle. A considerable amount of energy originating from the sun was spent to yield the high degree of order intrinsic to biomass. By directing the flow of energy carefully and selectively throughout the routes from initial biomass fractionation to downstream products in such a way that entropy increases only in controlled and measured amounts, Annikki is making chemical processing of biobased materials environmentally sustainable, all the while driving down the cost of manufacturing significantly. Annikki will present the fundamentals of a biomass fractionation concept and subsequent biocatalytic transformation processes adhering to such principles. This approach is very different from classical chemical manufacturing and has very broad applications in the manufacture of biobased chemicals.